Uncontrolled Innate and Impaired Adaptive Immune Responses in Patients with COVID-19 ARDS.
Identifieur interne : 000313 ( Main/Exploration ); précédent : 000312; suivant : 000314Uncontrolled Innate and Impaired Adaptive Immune Responses in Patients with COVID-19 ARDS.
Auteurs : Sophie Hue [France] ; Asma Beldi-Ferchiou [France] ; Inès Bendib [France] ; Mathieu Surenaud [France] ; Slim Fourati [France] ; Thomas Frapard [France] ; Simon Rivoal [France] ; Keyvan Razazi [France] ; Guillaume Carteaux [France] ; Marie-Hélène Delfau-Larue [France] ; Armand Mekontso Dessap [France] ; Etienne Audureau [France] ; Nicolas De Prost [France]Source :
- American journal of respiratory and critical care medicine [ 1535-4970 ] ; 2020.
Abstract
RATIONALE
Uncontrolled inflammatory innate response and impaired adaptive immune response are associated with clinical severity in patients with Coronavirus disease 2019 (COVID-19).
OBJECTIVES
To compare the immunopathology of COVID-19 acute respiratory distress syndrome (ARDS) to that of non-COVID-19 ARDS, and to identify biomarkers associated with mortality in patients with COVID-19 ARDS.
METHODS
Prospective observational monocenter study. Immunocompetent patients diagnosed with RT-PCR-confirmed SARS-CoV-2 infection and ARDS admitted between March 8 and March 30, 2020 were included and compared with patients with non-COVID-19 ARDS. The primary clinical endpoint of the study was mortality at day 28. Flow cytometry analyses and serum cytokines measurements were performed at days 1-2 and 4-6 of ICU admission.
MEASUREMENTS AND MAIN RESULTS
As compared with patients with non-COVID-19 ARDS (n=36), those with COVID-19 (n=38) were not significantly different regarding age, gender, and SOFA and SAPS II scores but exhibited a higher day-28 mortality (34% vs 11%, p=0.030). COVID-19 patients showed profound and sustained T CD4+ (p=0.002), CD8+ (p<0.0001) and B (p<0.0001) lymphopenia, higher HLA-DR expression on monocytes (p<0.001) and higher serum concentrations of EGF, GM-CSF, IL-10, CCL2/MCP-1, CCL3/MIP-1a, CXCL10/IP-10, CCL5/RANTES, and CCL20/MIP-3a. After adjusting on age and SOFA, serum CXCL10/IP-10 (p=0.047) and GM-CSF (p=0.050) were higher and naso-pharyngeal RT-PCR cycle threshold values lower (p=0.010) in COVID-19 patients who were dead at day-28.
CONCLUSIONS
Profound global lymphopenia and a "chemokine signature" were observed in COVID-19 ARDS. Increased serum concentrations of CXCL10/IP-10 and GM-CSF, together with higher naso-pharyngeal SARS-CoV-2 viral load, were associated with day-28 mortality. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI: 10.1164/rccm.202005-1885OC
PubMed: 32866033
Affiliations:
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type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche CARMAS, Creteil, France; nicolas.de-prost@aphp.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche CARMAS, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName><orgName type="university">Université Paris-Est Créteil Val-de-Marne</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32866033</idno><idno type="pmid">32866033</idno><idno type="doi">10.1164/rccm.202005-1885OC</idno><idno type="wicri:Area/Main/Corpus">000288</idno><idno type="wicri:explorRef" wicri:stream="Main" 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type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université Paris Est Créteil, Faculté de Médecine, IMRB, team 16, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est Créteil, Faculté de Médecine, IMRB, team 16, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Beldi Ferchiou, Asma" sort="Beldi Ferchiou, Asma" uniqKey="Beldi Ferchiou A" first="Asma" last="Beldi-Ferchiou">Asma Beldi-Ferchiou</name><affiliation wicri:level="3"><nlm:affiliation>Henri Mondor Hospital, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Henri Mondor Hospital, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Bendib, Ines" sort="Bendib, Ines" uniqKey="Bendib I" first="Inès" last="Bendib">Inès Bendib</name><affiliation wicri:level="3"><nlm:affiliation>Henri Mondor Hospital, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Henri Mondor Hospital, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Surenaud, Mathieu" sort="Surenaud, Mathieu" uniqKey="Surenaud M" first="Mathieu" last="Surenaud">Mathieu Surenaud</name><affiliation wicri:level="3"><nlm:affiliation>Universite Paris-Est Creteil Val de Marne Faculte de medecine, 60967, INSERM U955, team 16, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Universite Paris-Est Creteil Val de Marne Faculte de medecine, 60967, INSERM U955, team 16, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Fourati, Slim" sort="Fourati, Slim" uniqKey="Fourati S" first="Slim" last="Fourati">Slim Fourati</name><affiliation wicri:level="3"><nlm:affiliation>Henri Mondor Hospital, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Henri Mondor Hospital, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Frapard, Thomas" sort="Frapard, Thomas" uniqKey="Frapard T" first="Thomas" last="Frapard">Thomas Frapard</name><affiliation wicri:level="3"><nlm:affiliation>Henri Mondor Hospital, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Henri Mondor Hospital, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Rivoal, Simon" sort="Rivoal, Simon" uniqKey="Rivoal S" first="Simon" last="Rivoal">Simon Rivoal</name><affiliation wicri:level="3"><nlm:affiliation>Henri Mondor Hospital, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Henri Mondor Hospital, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Razazi, Keyvan" sort="Razazi, Keyvan" uniqKey="Razazi K" first="Keyvan" last="Razazi">Keyvan Razazi</name><affiliation wicri:level="3"><nlm:affiliation>Hopitaux Universitaires Henri Mondor, 378967, Medical Intensive Care Unit, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopitaux Universitaires Henri Mondor, 378967, Medical Intensive Care Unit, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche Clinique CARMAS, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche Clinique CARMAS, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName><orgName type="university">Université Paris-Est Créteil Val-de-Marne</orgName></affiliation></author><author><name sortKey="Carteaux, Guillaume" sort="Carteaux, Guillaume" uniqKey="Carteaux G" first="Guillaume" last="Carteaux">Guillaume Carteaux</name><affiliation wicri:level="3"><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor, Service de réanimation médicale, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor, Service de réanimation médicale, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université Paris Est Créteil, Faculté de Médecine de Créteil, Groupe de recherche clinique CARMAS, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est Créteil, Faculté de Médecine de Créteil, Groupe de recherche clinique CARMAS, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Delfau Larue, Marie Helene" sort="Delfau Larue, Marie Helene" uniqKey="Delfau Larue M" first="Marie-Hélène" last="Delfau-Larue">Marie-Hélène Delfau-Larue</name><affiliation wicri:level="3"><nlm:affiliation>Henri Mondor Hospital, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Henri Mondor Hospital, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Mekontso Dessap, Armand" sort="Mekontso Dessap, Armand" uniqKey="Mekontso Dessap A" first="Armand" last="Mekontso Dessap">Armand Mekontso Dessap</name><affiliation wicri:level="3"><nlm:affiliation>Hopital Henri Mondor, Service de Réanimation Médicale, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Henri Mondor, Service de Réanimation Médicale, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UPEC, Groupe de recherche clinique CARMAS, IMRB, Faculté de médecine de Créteil, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UPEC, Groupe de recherche clinique CARMAS, IMRB, Faculté de médecine de Créteil, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Audureau, Etienne" sort="Audureau, Etienne" uniqKey="Audureau E" first="Etienne" last="Audureau">Etienne Audureau</name><affiliation wicri:level="3"><nlm:affiliation>APHP Hôpital Henri Mondor, Santé Publique, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHP Hôpital Henri Mondor, Santé Publique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="De Prost, Nicolas" sort="De Prost, Nicolas" uniqKey="De Prost N" first="Nicolas" last="De Prost">Nicolas De Prost</name><affiliation wicri:level="3"><nlm:affiliation>Hopital Henri Mondor, 55471, DHU A-TVB, Service de Réanimation Médicale, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Henri Mondor, 55471, DHU A-TVB, Service de Réanimation Médicale, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche CARMAS, Creteil, France; nicolas.de-prost@aphp.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche CARMAS, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName><orgName type="university">Université Paris-Est Créteil Val-de-Marne</orgName></affiliation></author></analytic><series><title level="j">American journal of respiratory and critical care medicine</title><idno type="eISSN">1535-4970</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>RATIONALE</b></p><p>Uncontrolled inflammatory innate response and impaired adaptive immune response are associated with clinical severity in patients with Coronavirus disease 2019 (COVID-19).</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To compare the immunopathology of COVID-19 acute respiratory distress syndrome (ARDS) to that of non-COVID-19 ARDS, and to identify biomarkers associated with mortality in patients with COVID-19 ARDS.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Prospective observational monocenter study. Immunocompetent patients diagnosed with RT-PCR-confirmed SARS-CoV-2 infection and ARDS admitted between March 8 and March 30, 2020 were included and compared with patients with non-COVID-19 ARDS. The primary clinical endpoint of the study was mortality at day 28. Flow cytometry analyses and serum cytokines measurements were performed at days 1-2 and 4-6 of ICU admission.</p></div><div type="abstract" xml:lang="en"><p><b>MEASUREMENTS AND MAIN RESULTS</b></p><p>As compared with patients with non-COVID-19 ARDS (n=36), those with COVID-19 (n=38) were not significantly different regarding age, gender, and SOFA and SAPS II scores but exhibited a higher day-28 mortality (34% vs 11%, p=0.030). COVID-19 patients showed profound and sustained T CD4+ (p=0.002), CD8+ (p<0.0001) and B (p<0.0001) lymphopenia, higher HLA-DR expression on monocytes (p<0.001) and higher serum concentrations of EGF, GM-CSF, IL-10, CCL2/MCP-1, CCL3/MIP-1a, CXCL10/IP-10, CCL5/RANTES, and CCL20/MIP-3a. After adjusting on age and SOFA, serum CXCL10/IP-10 (p=0.047) and GM-CSF (p=0.050) were higher and naso-pharyngeal RT-PCR cycle threshold values lower (p=0.010) in COVID-19 patients who were dead at day-28.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Profound global lymphopenia and a "chemokine signature" were observed in COVID-19 ARDS. Increased serum concentrations of CXCL10/IP-10 and GM-CSF, together with higher naso-pharyngeal SARS-CoV-2 viral load, were associated with day-28 mortality. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32866033</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1535-4970</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>31</Day></PubDate></JournalIssue><Title>American journal of respiratory and critical care medicine</Title><ISOAbbreviation>Am. J. Respir. Crit. Care Med.</ISOAbbreviation></Journal><ArticleTitle>Uncontrolled Innate and Impaired Adaptive Immune Responses in Patients with COVID-19 ARDS.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1164/rccm.202005-1885OC</ELocationID><Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Uncontrolled inflammatory innate response and impaired adaptive immune response are associated with clinical severity in patients with Coronavirus disease 2019 (COVID-19).</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To compare the immunopathology of COVID-19 acute respiratory distress syndrome (ARDS) to that of non-COVID-19 ARDS, and to identify biomarkers associated with mortality in patients with COVID-19 ARDS.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Prospective observational monocenter study. Immunocompetent patients diagnosed with RT-PCR-confirmed SARS-CoV-2 infection and ARDS admitted between March 8 and March 30, 2020 were included and compared with patients with non-COVID-19 ARDS. The primary clinical endpoint of the study was mortality at day 28. Flow cytometry analyses and serum cytokines measurements were performed at days 1-2 and 4-6 of ICU admission.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">As compared with patients with non-COVID-19 ARDS (n=36), those with COVID-19 (n=38) were not significantly different regarding age, gender, and SOFA and SAPS II scores but exhibited a higher day-28 mortality (34% vs 11%, p=0.030). COVID-19 patients showed profound and sustained T CD4+ (p=0.002), CD8+ (p<0.0001) and B (p<0.0001) lymphopenia, higher HLA-DR expression on monocytes (p<0.001) and higher serum concentrations of EGF, GM-CSF, IL-10, CCL2/MCP-1, CCL3/MIP-1a, CXCL10/IP-10, CCL5/RANTES, and CCL20/MIP-3a. After adjusting on age and SOFA, serum CXCL10/IP-10 (p=0.047) and GM-CSF (p=0.050) were higher and naso-pharyngeal RT-PCR cycle threshold values lower (p=0.010) in COVID-19 patients who were dead at day-28.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Profound global lymphopenia and a "chemokine signature" were observed in COVID-19 ARDS. Increased serum concentrations of CXCL10/IP-10 and GM-CSF, together with higher naso-pharyngeal SARS-CoV-2 viral load, were associated with day-28 mortality. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hue</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hopitaux Universitaires Henri Mondor, 378967, Service d'immunologie, Creteil, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Est Créteil, Faculté de Médecine, IMRB, team 16, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beldi-Ferchiou</LastName><ForeName>Asma</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Henri Mondor Hospital, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bendib</LastName><ForeName>Inès</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Henri Mondor Hospital, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Surenaud</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Universite Paris-Est Creteil Val de Marne Faculte de medecine, 60967, INSERM U955, team 16, Creteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fourati</LastName><ForeName>Slim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Henri Mondor Hospital, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frapard</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Henri Mondor Hospital, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivoal</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Henri Mondor Hospital, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Razazi</LastName><ForeName>Keyvan</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Hopitaux Universitaires Henri Mondor, 378967, Medical Intensive Care Unit, Creteil, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche Clinique CARMAS, Creteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carteaux</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor, Service de réanimation médicale, Créteil, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Est Créteil, Faculté de Médecine de Créteil, Groupe de recherche clinique CARMAS, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delfau-Larue</LastName><ForeName>Marie-Hélène</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Henri Mondor Hospital, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mekontso Dessap</LastName><ForeName>Armand</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hopital Henri Mondor, Service de Réanimation Médicale, Creteil, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UPEC, Groupe de recherche clinique CARMAS, IMRB, Faculté de médecine de Créteil, Creteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Audureau</LastName><ForeName>Etienne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>APHP Hôpital Henri Mondor, Santé Publique, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Prost</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Hopital Henri Mondor, 55471, DHU A-TVB, Service de Réanimation Médicale, Creteil, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universite Paris-Est Creteil Val de Marne, 27010, Groupe de Recherche CARMAS, Creteil, France; nicolas.de-prost@aphp.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Respir Crit Care Med</MedlineTA><NlmUniqueID>9421642</NlmUniqueID><ISSNLinking>1073-449X</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS-CoV-2, COVID-19, ARDS, chemokines, cytokines</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32866033</ArticleId><ArticleId IdType="doi">10.1164/rccm.202005-1885OC</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Créteil</li></settlement><orgName><li>Université Paris-Est Créteil Val-de-Marne</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Hue, Sophie" sort="Hue, Sophie" uniqKey="Hue S" first="Sophie" last="Hue">Sophie Hue</name></region><name sortKey="Audureau, Etienne" sort="Audureau, Etienne" uniqKey="Audureau E" first="Etienne" last="Audureau">Etienne Audureau</name><name sortKey="Beldi Ferchiou, Asma" sort="Beldi Ferchiou, Asma" uniqKey="Beldi Ferchiou A" first="Asma" last="Beldi-Ferchiou">Asma Beldi-Ferchiou</name><name sortKey="Bendib, Ines" sort="Bendib, Ines" uniqKey="Bendib I" first="Inès" last="Bendib">Inès Bendib</name><name sortKey="Carteaux, Guillaume" sort="Carteaux, Guillaume" uniqKey="Carteaux G" first="Guillaume" last="Carteaux">Guillaume Carteaux</name><name sortKey="Carteaux, Guillaume" sort="Carteaux, Guillaume" uniqKey="Carteaux G" first="Guillaume" last="Carteaux">Guillaume Carteaux</name><name sortKey="De Prost, Nicolas" sort="De Prost, Nicolas" uniqKey="De Prost N" first="Nicolas" last="De Prost">Nicolas De Prost</name><name sortKey="De Prost, Nicolas" sort="De Prost, Nicolas" uniqKey="De Prost N" first="Nicolas" last="De Prost">Nicolas De Prost</name><name sortKey="Delfau Larue, Marie Helene" sort="Delfau Larue, Marie Helene" uniqKey="Delfau Larue M" first="Marie-Hélène" last="Delfau-Larue">Marie-Hélène Delfau-Larue</name><name sortKey="Fourati, Slim" sort="Fourati, Slim" uniqKey="Fourati S" first="Slim" last="Fourati">Slim Fourati</name><name sortKey="Frapard, Thomas" sort="Frapard, Thomas" uniqKey="Frapard T" first="Thomas" last="Frapard">Thomas Frapard</name><name sortKey="Hue, Sophie" sort="Hue, Sophie" uniqKey="Hue S" first="Sophie" last="Hue">Sophie Hue</name><name sortKey="Mekontso Dessap, Armand" sort="Mekontso Dessap, Armand" uniqKey="Mekontso Dessap A" first="Armand" last="Mekontso Dessap">Armand Mekontso Dessap</name><name sortKey="Mekontso Dessap, Armand" sort="Mekontso Dessap, Armand" uniqKey="Mekontso Dessap A" first="Armand" last="Mekontso Dessap">Armand Mekontso Dessap</name><name sortKey="Razazi, Keyvan" sort="Razazi, Keyvan" uniqKey="Razazi K" first="Keyvan" last="Razazi">Keyvan Razazi</name><name sortKey="Razazi, Keyvan" sort="Razazi, Keyvan" uniqKey="Razazi K" first="Keyvan" last="Razazi">Keyvan Razazi</name><name sortKey="Rivoal, Simon" sort="Rivoal, Simon" uniqKey="Rivoal S" first="Simon" last="Rivoal">Simon Rivoal</name><name sortKey="Surenaud, Mathieu" sort="Surenaud, Mathieu" uniqKey="Surenaud M" first="Mathieu" last="Surenaud">Mathieu Surenaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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